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KMID : 0869619990160010026
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Journal of Korean Society of Hospital Pharmacists
1999 Volume.16 No. 1 p.26 ~ p.33
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Compatibility Test of Neonatal Parenteral Nutrient Solutions with Ceftriaxone
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Abstract
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The purpose of this study was to evaluate the compatibility/stability of ceftriaxone with neonatal parenteral nutrient solutions. The concentration of ceftriaxone was determined by recommended dosage commonly used in NICU. Two neonatal parenteral nutrient solutions were mixed with TrophAmine. Admixture was prepare in duplicate and stored at 37℃ water bath for each hour. Each mixture was investigated for pH, visual inspection, HPLC assay of ceftriaxone, atomic absorption spectrometry of calcium ion. An obvious precipitate which occurred with 1-4 hours after mixing with PN solution was yielded on these mixtures. Despite various aspects of precipitations, calcium salts of ceftriaxone/calcium ion decreased to 20-80%. Accordingly, if ceftriaxone is administered through the PN line, flush the line with normal saline before and after each administration. The infusion of parenteral nutrient solution should be temporily stopped during adminstration the ceftriaxone.
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